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KMID : 1102220160350040259
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Kidney Research and Clinical Practice
2016 Volume.35 No. 4 p.259 ~ p.262
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Crystalline podocytopathy and tubulopathy without overt glomerular proteinuria in a patient with multiple myeloma
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Lee Eun-Jeong
Lee Su-Yeon
Park So-Young
Kim Yon-Jin
Choi Jae-Shin
Kim Mi-Jeoung
Park Ji-Hyeon
Lee Jung-Eun
Kwon Ghee-Young
Kim Yoon-Goo
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Abstract
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Crystalline nephropathy is a rare yet well-known condition associated with multiple myeloma and other light chainesecreting disorders. Paraproteins that are resistant to proteolysis crystallize within proximal tubular cells and cause light-chain proximal tubulopathy, which presents clinically as Fanconi syndrome. Podocytes are rarely affected, and the crystalline inclusions within podocytes are typically precipitated, yielding significant glomerular proteinuria. Here we report a case of extensive crystalline inclusions primarily within podocytes and proximal tubules that presented only with Fanconi syndrome and renal insufficiency. Despite the presence of extensive crystalline inclusions in podocytes and diffuse foot process effacement, the patient had no clinical evidence suggestive of podocyte injury.
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KEYWORD
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Fanconi syndrome, Multiple myeloma, Nephropathy
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